In a small proportion (<2%) of toxins, 1 antidotes have been identified. “Treat the patient, not the toxin” is hence the guiding dictum in clinical toxicology. The latter list by far exceeds the former and hence the most important guiding principle in such emergencies is good supportive care while the patient recovers. In general, toxic agents can be classified into two groups: those for which specific treatment exists and others for which there is no specific therapy. Toxicological emergencies are encountered frequently in intensive care unit (ICU) practice, either as a result of drug overdose (accidental or suicidal) or due to drug toxicity secondary to inappropriate drug dosing or drug interactions. This review provides an overview of the role of antidotes in poisoning. Vitamins such as vitamin K, folic acid and pyridoxine are used to antagonise the effects of warfarin, methotrexate and INH respectively in the setting of toxicity or overdose. Drugs such as atropine and magnesium are used to counteract the end-organ effects in organophosphorus poisoning. Drugs such as N-acetyl cysteine and sodium thiocyanate reduce the formation of toxic metabolites in paracetamol and cyanide poisoning respectively. naloxone, flumazenil) are other mechanisms by which antidotes act. oximes for organophosphorus poisoning) and competitive receptor blockade (e.g. ethanol for methanol poisoning), enhancement of enzyme function (e.g. In some situations, enhanced elimination can be achieved by urinary alkalization or hemadsorption. Specific binders include chelating agents, bioscavenger therapy and immunotherapy. The most commonly used non-specific binding agent is activated charcoal. #Define antidote freeBut antidote, is anti-poison, so dote on situations that require antidotes - your life may be on the line.Reduction in free toxin level can be achieved by specific and non-specific agents that bind to the toxin. They're fun, but they don't change your destiny. ( Daily Mail.uk)įorced blossoms are an antidote to the gloomy winter months ( )Īn anecdote is a memoir sound bite, a little story. Then he told the physician there was only one way to save Wang's life - an antidote called Prussian Blue. It is also used figuratively for anything that neutralizes or counterbalances an unpleasant feeling or situation. It's an actual counteragent to a poison, like snake venom. ( New York Times)Īn antidote cures what ails you. Smith offered only anecdotes to back his beliefs. ( Miranda Eliot Swan)Ĭhrissie eagerly took up the subject and soon both veterans were coming out with anecdotes about all the hilarious things Martin had got up to. Anecdotes can be true or false they're revealing little tales:Īll the little anecdotes I had heard of him pleased me very much. That rattlesnake encounter? Well, maybe you embellished a bit - you saw a rattlesnake, but it didn't bite you. Tell someone an anecdote about your close encounter with a rattlesnake and how the cute park ranger had to get you the antidote for snake venom right away.Īn anecdote is a story someone tells about themselves or people they know. An anecdote is a funny little story an antidote counteracts poison.
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